objective(s): to investigate the chronopharmacological effects of growth hormone on executive function and the oxidative stress response in rats. materials and methods: fifty male wistar rats (36-40 weeks old) had ad libitum access to water and food and were separated into four groups: diurnal control, nocturnal control, diurnal gh-treated, and nocturnal gh-treated animals. levels of cu, zn sup...

Antioxidant activity of Berry (Morus alba var. nigra) was investigated. For superoxide anion radical assay, the superoxide anion radicals were generated by a pyrogallol auto oxidation system, Nitric oxide radical inhibition by the use of Griess Illosvoy reaction and reducing power was determined according to the Oyaizu method. At least this sample was represented a potential antioxidant capacit...

introduction: perepubertal varicocele can result in hypotrophy of testes, sperm damage and decrease the function of leydig cells in future. pathophysiology of varicocele is unclear. increased reactive oxygen species (ros) is a major theory. there are many controversies in treatment of pediatric varicocele. flaxseed (fs) is the richest source of lignans with antioxidant properties. the aim of th...

Inhibition of tumor necrosis factor-alpha (TNFα) and superoxide anion production reduces inflammation and pain. The present study investigated whether superoxide anion-induced pain depends on TNFα signaling and the role of superoxide anion in TNFα-induced hyperalgesia to clarify the interrelation between these two mediators in the context of pain. Intraplantar injection of a superoxide anion do...

Monocyte extravasation into the vessel wall has been shown to be a critical step in the development of atherosclerosis. Upon activation, monocytes produce a burst of superoxide anion due to activation of the NADPH oxidase enzyme complex. Monocyte-derived superoxide anion contributes to oxidant stress in inflammatory sites, is required for monocyte-mediated LDL oxidation, and alters basic cell f...

It has been generally accepted that superoxide anion generated by the mitochondrial respiratory transport chain are vectorially released into the mitochondrial matrix, where they are converted to hydrogen peroxide through the catalytic action of Mn-superoxide dismutase. Release of superoxide anion into the intermembrane space is a controversial topic, partly unresolved by the reaction of supero...

In vivo endotoxin infusion produces neutrophil-mediated acute lung injury and increases superoxide anion release from phorbol myristate acetate (PMA) -stimulated blood neutrophils collected 18-24 hours after the infusion. Because the turnover time of circulating blood neutrophils is only 6-8 hours, it was hypothesized that the prolonged increase in superoxide anion release from peripheral blood...

Exogenous diacylglycerols stimulate neutrophil superoxide anion production, suggesting that endogenous diacylglycerols may function as second messengers for this biological response. We have measured the diacylglycerol mass in human neutrophils stimulated by fMet-Leu-Phe, ionomycin, and concanavalin A and have correlated the kinetics and magnitude of the diacylglycerol response with those for s...

In this study, ethanol extract of Carthamustinctoriuswas studied for superoxide anion scavenging activity. The antioxidant properties of Carthamustinctorius ethanol extract was evaluated using superoxide anion radical scavenging activities. The extract of Carthamustinctorius exhibited strong total antioxidant activity and superoxide anion scavenging activity. This antioxidant activity test were...

We have measured the rates of superoxide anion generation by cytochrome bc(1) complexes isolated from bovine heart and yeast mitochondria and by cytochrome bc(1) complexes from yeast mutants in which the midpoint potentials of the cytochrome b hemes and the Rieske iron-sulfur cluster were altered by mutations in those proteins. With all of the bc(1) complexes the rate of superoxide anion produc...